Dr. Sengupta obtained his B.Sc. (Hons.) degree in Zoology from Presidency College and his M.Sc. in Zoology from the University of Calcutta, India. Dr. Sengupta started his research career under the supervision of Dr. Kunal Ray in the Molecular and Human Genetics Division at CSIR-Indian Institute of Chemical Biology. The broad area of his research has been Molecular Genetics of Human Genetic Disorders. In course of his research, he has worked on various aspects of human genetics including "Toxicogenomics and cytogenetics studies on Arsenic exposed populations", "Molecular genetics on oculocutaneous albinism" and "Genetic basis of Wilsons Disease". He earned his Ph.D. (Life Science) from Jadavpur University in 2010 on his studies of Genetic and Molecular Basis of Albinism in Indian Patients. Dr. Sengupta has also actively participated in the studies conducted for genotyping 1000 medically important genes by Indian Genome Variation Consortium taken up as a CSIR network project, and has majorly contributed to the development of Indian Genetic Disease Database (IGDD) that was accepted as a featured article in Nucleic Acids Research in 2011.

In October, 2012, Dr. Sengupta was selected as an Assistant Professsor, Department of Genetics, University of Calcutta. Currently, he is studying genetic defects associated with human diseases, especially pigmentation disorders like oculocutaneous albinism, Hemophilia, cigarette smoke induced lung cancer and Wilson’s Disease. He practice both dry and wet lab approaches to study genetic variations associated with diseases. He has also been engaged in updation and analysis of the Indian Genetic Disease Database