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Trifluoperazine is more effective than chlorpromazine in releasing oxygen from haemoglobin and myoglobin
J BHATTACHARYYA, M BHATTACHARYYA, A S CHAKRABORTI, U CHAUDHURI, R K PODDAR
Published in Blackwell Publishing Ltd
1996
Volume: 48
   
Issue: 9
Pages: 965 - 967
Abstract
The extent of oxygen release from two heme proteins, haemoglobin and myoglobin have been studied in the presence of trifluoperazine and chlorpromazine (5-1000 μM). At a molar ratio (drug:protein) of 1.5, the release of oxygen from haemoglobin was 4 and 15% in the presence of chlorpromazine and trifluoperazine respectively, while from myoglobin the corresponding values were 20 and 40%. The findings were attributed to the greater extent of local conformational change around tryptophan moieties of each of the proteins induced by trifluoperazine.
About the journal
JournalJournal of Pharmacy and Pharmacology
PublisherBlackwell Publishing Ltd
ISSN0022-3573