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The role of alpha-2U-globulin in corticosteroidogenesis in male rats
P K GHOSH, N M BISWAS
Published in -
1988
Volume: 31
   
Issue: 5
Pages: 773 - 775
Abstract
Administration of estradiol-17β for 7 days to the adult male rat results in adrenal hyperplasia, decreased serum corticosterone along with elevation in serum ACTH and inhibition of adrenal 5-ene-3β-hydroxysteroid dehydrogenase activity (5-ene-3β-HSD). Treatment with α2u-globulin for following 14 days of estrogen-treated rats reversed the effects of estrogen while in normal rats α2u-globulin treatment increased adrenal 5-ene-3β-HSD activity and serum corticosterone level while causing a fall in serum ACTH. It is concluded that α2u-globulin may play a role in ACTH secretion by inducing corticosterone synthesis. © 1988.
About the journal
JournalJournal of Steroid Biochemistry
Publisher-
ISSN0022-4731