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The effects of lanthanum chloride administration in newborn chicks on glutamate uptake and release by brain synaptosomes
A BASU, K CHAKRABARTY, S HALDAR, S ADDYA, G C CHATTERJEE
Published in ELSEVIER SCI IRELAND LTD
1984
Volume: 20
   
Issue: 3
Pages: 303 - 308
Abstract
Acute i.p. administration of lanthanum chloride to newborn chicks at a single dose of 250 mg/kg body weight causes inhibition of the high affinity uptake of [14C]glutamate by isolated brain synaptosomes. There is also a marked decrease in the release of preloaded [14C]glutamate from brain synaptosomes in the presence of externally available Ca2+ (1.2 mM) or a high K+ concentration (71 mM). The inhibition of glutamate release has been discussed in relation to depletion of Ca2+ binding to the synaptosomal membrane under lanthanum intoxication. © 1984.
About the journal
JournalData powered by TypesetToxicology Letters
PublisherData powered by TypesetELSEVIER SCI IRELAND LTD
ISSN0378-4274