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Synthesis of Novel tricyclic pyrazolo(1,4)oxathiinopyrazines and Evaluation of Their Competency Towards the Inhibition of Lactate Dehydrogenase Activity-Inhibition of LDH Activity
, , R MISHRA, S BHOWMICK,
Published in Georg Thieme Verlag
2018
PMID: 29895087
Volume: 68
   
Issue: 11
Pages: 653 - 660
Abstract
We have evaluated the LDH inhibitory property of novel pyrazolo[4′,3′:5,6][1,4]oxathiino[2,3-b]pyrazine derivatives which have been synthesized from easily available starting materials through a one-pot protocol that offers the use of elemental sulfur as the sulfur source. These newly synthesized compounds may aid to drug development for neoplastic and non-neoplastic diseases characterized by increased glucose metabolism. Additionally, they may act as suitable starting materials which can be further structurally modified for the development of new LDH inhibitors with higher efficacy and specificity. © Georg Thieme Verlag KG Stuttgart. New York.
About the journal
JournalDrug Research
PublisherGeorg Thieme Verlag
ISSN2194-9379
Open AccessYes
Authors (3)