A simple and efficient one-pot methodology has been developed for the synthesis of biologically important multi-functionalized 3-(2′-hydroxyaryl)-2-(2′-carboxyphenyl)benzofurans using silica sulfuric acid (SSA) as a heterogeneous acid catalyst in DMF medium. The significant advantages of this methodology are the use of SSA as a recyclable solid acid catalyst, operational simplicity, easy availability of the starting materials, and good yield of the products with high atom-economy. © 2016, Springer International Publishing Switzerland.

ANIMESH PRAMANIK

Chemistry

A KUNDU

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Molecular Diversity

Abstract: A convenient protocol for the library synthesis of biologically important 1-aryl-2′,6-spiro(1′,3′-indanedione)-1H-indeno[1,2-b]quinoline-5,7-diones has been developed. In this one-pot reaction protocol a tetrone is condensed with various N-aryl/alkylenamines of 1,3-cyclohexadiones on the surface of a solid-supported acid catalyst silica sulfuric acid under solvent-free condition. The significant advantages of this methodology are the use of solvent-free reaction conditions, operational simplicity of the reaction, good yield of the products with high atom economy, and employment of a recyclable catalyst. All these favorable factors make the present method convenient, economic, and ‘benign by design’. Graphical Abstract: Novel synthesis of a series of spiro 1,3-indanedione-fused dihydropyridines through the condensation of a tetrone with N-aryl/alkylenamines in presence of solid support silica sulfuric acid. [Figure not available: see fulltext.] © 2015, Springer International Publishing Switzerland.

Novel synthesis of a series of spiro 1,3-indanedione-fused dihydropyridines through the condensation of a tetrone with N-aryl/alkylenamines in presence of solid support silica sulfuric acid

A series of biologically important isoindolone embedded heterocycles such as tetracyclic 2,4-diamino-5-aryl-10-oxo-10H-1,10a-diazaindeno[2,1-a]indene-3- carbonitriles and tricyclic 1-aryl-3,5-dioxo-1H-imidazo-[3,4-b]isoindoles have been synthesized from an easily derived common intermediate, 3-(2′-hydroxyaroyl)-2,3-dihydroisoindol-1-ones. The significant advantages of the present methodologies are the use of simple and easily available starting materials and reagents, operational simplicity, and good yields of the products with high atom-economy. © 2014 Elsevier Ltd. All rights reserved.

Tetrahedron Letters

Synthesis of different isoindolone embedded heterocycles with phenolic subunits from a common intermediate, 3-(2â€²-hydroxyaroyl)-2,3- dihydroisoindol-1-ones

A highly efficient protocol for the library synthesis of biologically important 3H,3′H-spiro[benzofuran-2,1′isobenzofuran]-3,3′- diones has been developed by employing silica sulfuric acid (SSA) as solid acid support under solvent-free condition. The dual characteristics of SSA, as an activating agent as well as oxidizing agent, have been well exposed in these syntheses. The intrinsic advantages of the methodology are the use of solvent-free reaction condition without using any toxic reagents or metal catalyst, operational simplicity, recyclability of the solid support, good availability of the starting materials, and excellent yields which make the method attractive, economic, and 'benign by design'. © 2014 Elsevier Ltd. All rights reserved.

Silica sulfuric acid: An efficient reusable heterogeneous solid support for the synthesis of 3H,3â€²H-spiro[benzofuran-2,1â€²isobenzofuran]-3, 3â€²-diones under solvent-free condition

An efficient methodology for the synthesis of 3H,3′H- spiro[benzofuran-2,1′-isoindole]-3,3′-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy.

Facile synthesis of 3H,3â€²H-spiro[benzofuran-2,1â€²-isoindole]-3, 3â€²-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent

A diastereoselective synthesis of isoindole-fused diazacyclooctaindenone derivatives has been accomplished through tandem ring-opening and ring-closing of spirochromene derivatives triggered by different aliphatic 1,2-diamines. When ethanolic solutions of spirochromenes are refluxed with different aliphatic 1,2-diamines such as 1,2-ethylenediamine, (±)-1,2-propylenediamine and (±)-trans-1,2-cyclohexanediamine, the isoindole-fused eight-membered heterocycles are formed in moderate to high yields within 5-15 min. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Journal	Data powered by TypesetMolecular Diversity
Publisher	Data powered by TypesetSpringer International Publishing
ISSN	1381-1991
Open Access	No