The observation and analyses of pre-seismic VLF electromagnetic (EM) signals recorded by VLF receivers at frequencies 5, 7, 9 and 12 kHz on November 16, 2008 over Kolkata (Lat. 22.56° N, Long. 88.5° E) during the large earthquake at Minahasa, Sulawesi, under Indonesia (Lat. 1.27° N, Long. 122.09° E) will be presented. Spiky variations of signals are observed few days prior to the day of occurrence of the earthquake which continued several days more, then decayed gradually and eventually ceased. These signals are critically examined to delineate their correlation with earthquake. The time variability of natural EM signals in the VLF band is juxtaposed with the pre-seismic records.