For the normal growth and development of the uterus, a balance of several functionally important biochemical components is essential. Uterine lipids, for example, are essential components which increase very significantly in quantity during maturity. Our present work shows that cannabis extract treatment significantly decreases the total lipid, cholesterol as well as phospholipid components of the uterus in young rats. When estradiol is given to cannabis-treated rats, the drug is found to inhibit the hormone primed rise in these components. As pointed out by our laboratory previously, these observations once again signify cannabis extract to have an antiestrogenic type of action on the young rat uterus.