A high yielding and fast method of Knoevenagel condensation of ethyl cyanoacetate with various aldehydes under microwave irradiation using environment-friendly ammonium acetate in the absence of any solvent is described.

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N KARCHAUDHURI

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Solvent-Free Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes

Synthetic Communications

Hexamethylenetetramine has been exploited for the first time successfully as a catalyst for the Doebner reaction and Knoevenagel condensation along with the rate enhancement by microwave irradiation under solvent-free conditions.

Journal of Chemical Research - Part S

Microwave-assisted condensation reactions exploiting hexamethylenetetramine as a catalyst under solvent-free conditions

A convenient approach for the synthesis of β-cyanoepoxides is illustrated by iodine(III)-catalyzed epoxidation of electron-deficient β-cyanostyrenes, wherein the active catalytic iodine(III) species was generated in situ. The epoxidation of β-cyanostyrenes was performed using 10 mol% PhI as precatalyst in the presence of 2.0 equivalents Oxone as an oxidant and 2.4 equivalents of TFA as an additive at room temperature under ultrasonic radiations. The β-cyanoepoxides were isolated in good to excellent yields in a short reaction time.

Fulltext

Synthesis

Hypervalent Iodine(III)-Catalyzed Epoxidation of β-Cyanostyrenes

A number of 3-substituted coumarins have been synthesized by palladium-catalysed coupling of 3-bromocoumarin with alkenes, cycloalkenes and alkyne.

Journal	Synthetic Communications
Publisher	Marcel Dekker Inc.
ISSN	0039-7911