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Silica sulfuric acid: A reusable solid catalyst for one pot synthesis of densely substituted pyrrole-fused isocoumarins under solvent-free conditions
S PATHAK, K DEBNATH,
Published in BEILSTEIN-INSTITUT
2013
Volume: 9
   
Pages: 2344 - 2353
Abstract
A convenient and efficient methodology for the synthesis of densely substituted pyrrole-fused isocoumarins, which employs solidsupported silica sulfuric acid (SSA) as catalyst, has been developed. When the mixture of ninhydrin adducts of acetylacetone/ethyl acetoacetate and primary amines was heated on the solid surface of SSA under solvent-free conditions, the pyrrole-fused isocoumarins were formed in good yields. This synthetic method has several advantages such as the employment of solvent-free reaction conditions without the use of any toxic reagents and metal catalysts, the ease of product isolation, the use of a recyclable catalyst, the low cost, the easy availability of the starting materials, and the excellent yields of products. © 2013 Pathak et al.
About the journal
JournalBeilstein Journal of Organic Chemistry
PublisherBEILSTEIN-INSTITUT
ISSN1860-5397
Open AccessNo