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Signal transduction and intracellular trafficking by the interleukin 36 receptor
, D. Singh, E.L. Raymond, R. Ganesan, G. Caviness, C. Grimaldi, Jr. Woska, D. Mennerich, S.-E. Brown, M.L. MbowShow More
Published in American Society for Biochemistry and Molecular Biology Inc.
2015
PMID: 26269592
Volume: 290
   
Issue: 39
Pages: 23997 - 24006
Abstract
Improper signaling of the IL-36 receptor (IL-36R), a member of the IL-1 receptor family, has been associated with various inflammation-associated diseases. However, the requirements for IL-36R signal transduction remain poorly characterized. This work seeks to define the requirements for IL-36R signaling and intracellular trafficking. In the absence of cognate agonists, IL-36R was endocytosed and recycled to the plasma membrane. In the presence of IL-36, IL-36R increased accumulation in LAMP1+ lysosomes. Endocytosis predominantly used a clathrin-mediated pathway, and the accumulation of the IL-36R in lysosomes did not result in increased receptor turnover. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R.
About the journal
JournalJournal of Biological Chemistry
PublisherAmerican Society for Biochemistry and Molecular Biology Inc.
ISSN00219258