The present work reports the synthesis of new generation semi-interpenetrating (s-IPN) hydrogels from carboxymethyl guar gum (CMGG) and gelatin with enhanced gel properties for suitable drug delivery applications. Hydrogels are three dimensional polymer networks which respond to water and ion interactions. Irreversible s-IPN hydrogels were prepared by CMGG interactions in gelatin and characterized in FT-IR, SEM and thermal studies. CMGG was synthesized by Hofmeister ion guided homogeneous phase reactions. The swelling kinetics of the newer s-IPN hydrogels followed Schott's pseudo second order model. Furthermore, the hydrogels were hemocompatible, non-cytotoxic and appropriate for applications in physiological environment. Model drug ciprofloxacin was loaded within the hydrogels and the drug release was found to be a combination of both diffusion and hydrogel degradation. New generation s-IPN biopolymer hydrogels of carboxymethyl guar gum and gelatin holds promise for its application as sustained drug delivery device or alternatively as hydrogel sorbents for bio-toxins and molecules of biomedical importance. © 2018 Elsevier B.V.