N SUBRAMANIAN

B K NANDI

A K MAJUMDER

I B CHATTERJEE

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Role of L-ascorbic acid on detoxification of histamine

Biochemical Pharmacology

A variety of stress conditions, namely, administration of vaccines, toxoids and dietary and physical stress in rats and guinea pigs led to an enhanced histamine formation or release in the system. Administration of large doses of ascorbic acid in any of the stressful situations resulted in a marked decrease in the urinary histamine level indicating detoxification of histamine in vivo. In the guinea pig, the utilization of ascorbic acid was significantly increased in different histamine forming or histamine releasing stress conditions. © 1974.

Effect of ascorbic acid on detoxification of histamine under stress conditions

Administration of a variety of drugs led to an increased histamine formation or release in the system, as evidenced by an enhanced histidine decarboxylase activity of gastric mucosa and increased urinary histamine level. In the rat, administration of ascorbic acid along with the drugs decreased the urinary histamine level, indicating detoxification of histamine in vivo. In the guinea pig, histamine-producing or histamine-releasing drugs resulted in a decreased urinary ascorbic acid level, indicating greater utilization of the vitamin. © 1974.

Effect of ascorbic acid on detoxification of histamine in rats and guinea pigs under drug treated conditions

Large doses of ascorbic acid had neither beneficial nor toxic effect on growth and maintenance of rats and guinea pigs fed a nutritionally balanced fortified wheat diet. However, a daily intake of 50 mg or more ascorbic acid was toxic to guinea pigs fed unfortified wheat diet. Supplementation of the unfortified wheat diet by casein counteracted the toxicity of large doses of ascorbic acid.

Journal of Nutrition

Effects of large doses of vitamin C in guinea pigs and rats

The ability to synthesize ascorbic acid is absent in the insects, invertebrates, and fishes. The biosynthetic capacity started in the kidney of amphibians, resided in the kidney of reptiles, became transferred to the liver of mammals, and finally disappeared from the guinea pig, the flying mammals, monkey, and man. A similar transition in the biosynthetic ability was observed in the branched evolution of the birds.

Science

Evolution and the biosynthesis of ascorbic acid

d-Glucofuranosiduronolactone conjugates, namely, semicarbazone, oxime, cyanohydrin, and thioacetal of d-glucurono-1,4-lactone, were converted to l-ascorbic acid by an enzyme system present in rat, goat, or rabbit liver microsomes. Guinea pig liver microsomes were ineffective. Neither methyl-d-glucofuranosiduronolactone nor any glucopyranosiduronic acid conjugates examined were converted into l-ascorbic acid. Methods of preparation and properties of d-glucurono-1,4-lactone semicarbazone and d-glucurono-1,4-lactone oxime have been described and a tentative mechanism of enzymic reduction of the conjugates into l-gulono-1,4-lactone has been suggested. A conjugate of d-glucurono-1,4-lactone and imidazole, which is a substrate for the microsomal enzyme leading to synthesis of l-ascorbic acid, has been identified in the urine of rat treated with chloretone, barbital, and 1,2-benzanthracene. It has been indicated that the enhanced synthesis of l-ascorbic acid after administration of various drugs and toxic chemical compounds is due to the induced formation of this endogenous substrate. © 1970.

Analytical Biochemistry

Enzymic synthesis of l-ascorbic acid from synthetic and biological d-glucurono-1,4-lactone conjugates

American Journal of Physiology-Legacy Content

Role of induced histamine in tourniquet shock in mice

DIN EN 60630:2016-07, Maximale Lampen-Hüllkurven für Glühlampen (IEC_60630:1994_+ A1:1997_+ A2:1998, modifiziert_+ A3:1999_+ A4:2002, modifiziert_+ A5:2005_+ A6:2009, modifiziert_+ A7:2014, modifiziert); Deutsche Fassung EN_60630:1998_+ A3:1999_+ A4:2003_+ A5:2005_+ A6:2009_+ A7:2015

Journal	Biochemical Pharmacology
Publisher	-
ISSN	0006-2952