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Role of indomethacin in reversal of the cadmium-induced stress effect on testicular Δ5-3β- and 17-β-hydroxysteroid dehydrogenase activities in albino rats
GUPTA R SEN, M SARKAR, N M BISWAS
Published in -
1996
Volume: 24
   
Issue: 11
Pages: 731 - 733
Abstract
The effect of indomethacin in cadmium-induced rats on accessory sex organs and adrenal weights and testicular Δ5-3β-hydroxysteroid dehydrogenase (Δ5-3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD) activities were studied at 72 h. Subcutaneous injection of a single dose of 0.45 mg cadmium chloride/100 g b.wt. resulted in a significant rise in adrenal weight but decreases in accessory sex organs weight and the activity of Δ5-3β-HSD and 17β-HSD after 72 h of injection. Simultaneous administration of indomethacin and cadmium prevented the rise in adrenal weight and decreased activity of Δ5-3β-HSD and 17β-HSD and the weight of accessory sex organs. It is inferred that indomethacin can protect the impairment of adrenal and male gonadal functions induced by cadmium in rats.
About the journal
JournalMedical Science Research
Publisher-
ISSN0269-8951