G C CHATTERJEE

P K MAJUMDER

S K BANERJEE

R K ROY

B RAY

D RUDRAPAL

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Annals of the New York Academy of Sciences

Adrenalectomy causes a significant decrease in the tissue levels of l-ascorbic acid. The ascorbic acid concentration is raised when adrenalectomized animals receive hydrocortisone. Various enzymes of l-ascorbic acid metabolism have been measured in rats after adrenalectomy and subsequent treatment with hydrocortisone and/or actinomycin D. Hydrocortisone stimulates the activity of liver gulono-oxidase responsible for the synthesis of l-ascorbic acid from l-gulonolactone. A slight increase in the activity of dehydroascorbatase is also observed in the adrenalectomized rats. Little change was observed in uronolactonase, l-gulonate dehydrogenase and l-gulonate decarboxylase activities. © 1973.

Biochemical Pharmacology

Effect of hydrocortisone on the metabolism of l-ascorbic acid in rats

Several enzymes of L-ascorbic acid metabolism have been estimated in the tissues of rats under conditions of alloxan diabetes and subsequent treatment with either insulin, insulin and actinomycin D or with insulin and cycloheximide. The enzyme "gulonooxidase" which is responsible for the biosynthesis of L-ascorbic acid from L-gulonolactone was found to be regulated by insulin at the post-transcriptional level. No pronounced effect was noted in the case of various other enzymes like dehydroascorbatase, uronolactonase, gulonate dehydrogenase and gulonate decarboxylase in rats under the identical experimental conditions. © 1973.

Effect of insulin on the metabolism of L-ascorbic acid in animals

(+)-Guaiacin, a trans(2,3)-trans(3,4) phenyltetralin lignan, has been isolated for the first time from the stem bark of Machilus edulis King (Lauraceae) together with dihydroguaiaretic acid. Contrary to earlier observations, (+)-guaiacin has been converted by two different routes to (+)-galbulin, a new optical antipode of (-)-galbulin. Physical properties including NMR and MS data as well as chemical degradation reactions are reported for the first time for these lignans. © 1972.

Phytochemistry

Lignans from Machilus edulis

IT has been reported1 that cyanide greatly stimulates the synthesis of L-ascorbic acid from D-glucuronolactone by the liver microsomes of the rat. By this method using cyanide it was found that either the liver or the kidney tissue of all the species examined which are known to be independent of an exogenous source of ascorbic acid was able to synthesize L-ascorbic acid, while the corresponding tissue of those which are dependent on such a source could not. Whether the enzyme system concerned was present in the liver or the kidney tissue depended on the position of the species in the phylogenetic scale of evolution2. This technique revealed further that, apart from man, monkey and the guinea pig, the India fruit bat (Pteropus medius) and the redvented bulbul (Pycnonotus cafer) were unable to synthesize L-ascorbic acid, and this was confirmed by the production of experimental scurvy in the bulbul and its cure by the administration of L-ascorbic acid3. This communication concerns the location of the genetic defect in all these species, which distinguishes them from those which can synthesize L-ascorbic acid. © 1961 Nature Publishing Group.

Journal	Annals of the New York Academy of Sciences
Publisher	-
ISSN	0077-8923