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Programmed supramolecular nanoassemblies: Enhanced serum stability and cell specific triggered release of anti-cancer drugs
S MONDAL, M SAHA, M GHOSH, S SANTRA, M A KHAN, SAHA K DAS,
Published in Royal Society of Chemistry
2019
Volume: 1
   
Issue: 4
Pages: 1571 - 1580
Abstract
A bolaamphiphilic cross-linked nanoassembly endowed with pH responsive degradation features has been designed and fabricated for stable noncovalent guest encapsulation and controlled release. The self-assembled bolaamphiphile is utilized to prepare cross-linked nanoassemblies to further stabilize the noncovalent guest encapsulation at a concentration below its critical aggregation concentration (CAC) in a large volume of water or serum for drug delivery applications. Thus, this system can simultaneously address premature drug release and safety issues. The nanoassemblies integrated with a β-thioester linker, which can be hydrolyzed selectively under mildly acidic conditions (pH ∼ 5.3) at a slow rate, thus enable controlled release of guest molecules. Biological evaluation revealed that doxorubicin loaded cross-linked nanoassemblies (CNs-DOX) are nontoxic to normal cells such as HEK-293 or PBMC, but in contrast, showed a robust apoptotic effect on colon cancer cells, HCT-116, indicating excellent specificity. Thus, the fabrication reproducibility, robust stability, triggered drug release and cell selective toxicity behavior make this small molecular system very promising in the field of chemotherapeutic applications. © 2019 The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetNanoscale Advances
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN2516-0230
Open AccessYes