Nicotine plays an important role on reproductive disorders, cardio-vascular diseases, different cancers and destruction of defence system in human. Its effect in protein malnourished condition is very little understood. This investigation was designed to determine the nicotine-induced toxicity (subcutaneously injected at a dose of 2.5 mg kg -1 b. wt. day -1 for 21 days) on different tissues of female albino rats and corresponding ameliorative observations of curcumin (orally supplemented at a dose of 80 mg kg -1 b. wt. day -1 during the treatment) under protein malnourished condition. Nicotine causes more significant (p<0.001) increase of glucose level, depletion protein and alteration of triglycerides and cholesterol levels in serum. Disruption of liver function and alteration of phosphatase enzymes are more significantly (p<0.001) occurred in protein restricted condition due to nicotine treatment. Nicotine also decreases the activity of antioxidant enzymes, increases lipid peroxidation and affects the production of female hormones more significantly (p<0.001) in such condition. Nicotine disrupts the structural integrity of ovary and uterus that may hamper normal pregnancy. Curcumin effectively ameliorates the deleterious effects of nicotine in protein malnourished condition and may be used in the diet as potential blocker of nicotine to protect the health of malnourished female population. © 2012 Academic Journals Inc.