Phospholipid synthesis, interconversion and breakdown in T. rubrum were followed by radioactive tracer. Synthesis and catabolism of phosphatidyl ethanolamine and phosphatidyl serine are most rapid; phosphatidyl choline and phosphatidyl inositol are metabolised rather slowly. Catabolism of phosphatidyl ethanolamine and phosphatidyl serine are uniform and their conversions to phosphatidyl choline and phosphatidyl inositol are suspected. © 1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

S K DAS

A B BANERJEE

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Phospholipid turnover in Trichophyton rubrum

Medical Mycology

At its minimum inhibitory concentration, undecanoic acid (UDA) inhibits biosynthesis of phosphatidyl serine, phosphatidyl ethanolamine and polyphosphoinositol but does not inhibit the synthesis of phosphatidyl glycerol, phosphatidyl choline, phosphatidyl inositol and phosphatidic acid in Trichophyton rubrum. At higher concentration, however, UDA inhibits biosynthesis of all phosphatides present in this dermatophyte. UDA also affects catabolism of these phosphatides. This inhibitory effect of UDA may be partially responsible for its toxic action on T. rubrum. © 1982 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Effect of undecanoic acid on phospholipid metabolismin trichophyton rubrum

Trichophyton rubrum cells contain lipase, phospholipases A and B and acyl CoA lysolecithin acyl transferase activities. This dermatophyte excretes lipase and phospholipase A into the growth medium when cultivated in Sabouraud's broth. Extracellular lipase has optimum activity at pH 8.0 whereas the intracellular lipase is maximally active at pH 8.0 whereas the intracellular lipase is maximally active at pH 7.0. The optimum pH of phospholipase A and B activities which are localized in 15000 g sedimentable cell fragments are 7.0 and 6.0 respectively. Supernatant obtained after removal of 1,005,000 g sedimentable fragments from cell extract contains acyl CoA lysolecithin acyl transferase which requires ATP, CoA, Mg2+ and an unsaturated fatty acid for its activity. © 1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Lipolytic enzymes of trichophyton rubrum

Trichophyton rubrum grown in Sabouraud's liquid medium contains phosphatidyl inositol, polyphosphatidyl inositol, phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine phosphatidyl glycerol and phosphatidic acid in the polar lipid fraction of its mycelia. The relative proportion of these components in total phospholipid fraction remains almost constant throughout the culture life of this fungus. © 1974 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Journal	Medical Mycology
Publisher	Informa Healthcare
ISSN	1369-3786