Jatropha is an important genus of the family Euphorbiaceae. The plants of this genus contain complex chemical constituents which are structurally impressive. The medicinal properties of the plants and their various constituents are valuable. We carried out phytochemical investigation on three Jatropha species, viz., Jatropha gossypifolia, Jatropha curcas and Jatropha multifida. We isolated several constituents: diterpenes, lignans, coumarinolignans and other compounds. Some of the isolates possess significant antibacterial and anticancer properties. Here, we discuss our phytochemical research on Jatropha species informing of the isolation, structures and bioactivity of their chemical constituents. © 2018 ARKAT USA, Inc.