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One-pot tandem cyclisation to pyrrolo[1,2-a][1,4]benzodiazepines: a modified approach to the Pictet-Spengler reaction
SK ASRAF ALI, SURESH KUMAR MONDAL, TAPAS DAS, SUSANTA KUMAR MANNA, ANIRBAN BERA, DEBABRATA DAFADAR, SOURENJIT NASKAR, , SHUBHANKAR SAMANTA
Published in ROYAL SOC CHEMISTRY
2019
Volume: 17
   
Issue: 18
Pages: 4652 - 4662
Abstract
We have reported a one-pot two-step methodology for the synthesis of highly condensed heterocycles, pyrrolo[1,2-a][1,4] benzodiazepines, by a modified Pictet-Spengler reaction under mild conditions in a short time. Our approach has a few advantages over the conventional two components synthesis as it is step and atom economic, environmentally benign and a convergent synthetic method. We have discussed here the broad substrate scope of this novel methodology.
About the journal
JournalOrganic and Biomolecular Chemistry
PublisherROYAL SOC CHEMISTRY
ISSN1477-0520