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One-pot tandem cyclisation to pyrrolo[1,2-: A] [1,4]benzodiazepines: A modified approach to the Pictet-Spengler reaction
S A ALI, S K MONDAL, T DAS, S K MANNA, A BERA, D DAFADAR, S NASKAR, , S SAMANTA
Published in Royal Society of Chemistry
2019
Volume: 17
   
Issue: 18
Pages: 4652 - 4662
Abstract
We have reported a one-pot two-step methodology for the synthesis of highly condensed heterocycles, pyrrolo[1,2-a][1,4]benzodiazepines, by a modified Pictet-Spengler reaction under mild conditions in a short time. Our approach has a few advantages over the conventional two components synthesis as it is step and atom economic, environmentally benign and a convergent synthetic method. We have discussed here the broad substrate scope of this novel methodology. © The Royal Society of Chemistry 2019.
About the journal
JournalData powered by TypesetOrganic and Biomolecular Chemistry
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN1477-0520