A one-flask thioetherification of pyrazolones has been demonstrated by transforming several pyrazolones to their corresponding 4-mercaptopyrazolone derivatives and employing them towards cross-coupling with various aromatic and heteroaromatic iodides by applying Pd(OAc)2/xantphos as the catalytic system. The coupling ability of these thiol intermediates with 2,3-dichloropyrazine through an aromatic SN2 pathway has also been established. This methodology provides the use of inexpensive starting materials along with a short reaction time. © 2017 The Royal Society of Chemistry.

ASISH DAS

Chemistry

PRASUN MUKHERJEE

GENERAL

P MUKHERJEE

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Organic and Biomolecular Chemistry

A practical ligand free Nano Nickel ferrite (NNF) catalysis has been established for the one pot direct sulfenylation of 4-hydroxycoumarin, 4-hydroxyquinolinone and pyrazolone derivatives by reacting them with several easily available aromatic iodides and elemental sulfur. Additionally, the protocol is highly facile for direct selenoetherification of 4-hydroxycoumarin, 4-hdroxyquinolinone scaffolds employing elemental selenium. The important aspects of this direct chalcogenation protocol are the use of easily recyclable nano Nickel ferrite catalyst, inexpensive reactants, use of elemental sulfur and selenium under aerobic condition. © 2019 Wiley-VCH Verlag GmbH &amp; Co. KGaA, Weinheim

ChemistrySelect

Magnetically Recyclable Nano Nickel Ferrite Catalyzed One-pot Chalcogenation of Bioactive Heterocycles Under Aerobic Condition

We have evaluated the LDH inhibitory property of novel pyrazolo[4′,3′:5,6][1,4]oxathiino[2,3-b]pyrazine derivatives which have been synthesized from easily available starting materials through a one-pot protocol that offers the use of elemental sulfur as the sulfur source. These newly synthesized compounds may aid to drug development for neoplastic and non-neoplastic diseases characterized by increased glucose metabolism. Additionally, they may act as suitable starting materials which can be further structurally modified for the development of new LDH inhibitors with higher efficacy and specificity. © Georg Thieme Verlag KG Stuttgart. New York.

Fulltext

Drug Research

Synthesis of Novel tricyclic pyrazolo(1,4)oxathiinopyrazines and Evaluation of Their Competency Towards the Inhibition of Lactate Dehydrogenase Activity-Inhibition of LDH Activity

A one-flask thioetherification of pyrazolones has been demonstrated by transforming several pyrazolones to their corresponding 4-mercaptopyrazolone derivatives and employing them towards cross-coupling with various aromatic and heteroaromatic iodides by applying Pd(OAc)(2)/xantphos as the catalytic system. The coupling ability of these thiol intermediates with 2,3-dichloropyrazine through an aromatic S(N)2 pathway has also been established. This methodology provides the use of inexpensive starting materials along with a short reaction time.

One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

A robust intramolecular cyclopropanation reaction was first performed on pyranopyrazole and pyranopyrimidine-dione derivatives to obtain spirocyclopropylpyrazolones and barbiturates, using iodosylbenzene (PhIO) or the combination of iodobenzene diacetate (PIDA)/molecular iodine (I2), under mild reaction conditions. Syntheses of functionally and stereochemically diversified, novel spiropyrazolone fused 2-iminothiophene and spiropyrazolone fused pyrroline scaffolds were also demonstrated via Lewis acid catalyzed highly diastereoselective (3 + 2) cycloaddition reactions of the synthesized spiro-cyclopropyl pyrazolones with phenyl isothiocyanate and benzonitrile, respectively. © 2017 American Chemical Society.

Journal of Organic Chemistry

Spirocyclopropanes from Intramolecular Cyclopropanation of Pyranopyrazoles and Pyranopyrimidine-diones and Lewis Acid Mediated (3 + 2) Cycloadditions of Spirocyclopropylpyrazolones

A series of novel coumarinyl 1,4-benzodioxanes were successfully synthesized from electronically diverse 2-[(o-iodophenoxy)methyl]oxiranes and different positional isomers of hydroxycoumarin via one-pot tandem nucleophilic displacement and copper-mediated intramolecular C-O coupling reaction using CuI and 1,10-phenanthroline as the efficient catalytic system. All the compounds were characterized by 1H, 13C NMR, IR, HRMS spectra and a selected set of newly synthesized compounds offered noticeable in vitro free hydroxyl radical scavenging activity in a systematic dose dependent manner which signifies their excellent biological potential. © 2012 Elsevier Ltd. All rights reserved.

Tetrahedron Letters

Design and synthesis of coumarinyl 1,4-benzodioxanes as potential anti-oxidant

The Journal of Organic Chemistry

Highly Active, Air-Stable Versatile Palladium Catalysts for the C−C, C−N, and C−S Bond Formations via Cross-Coupling Reactions of Aryl Chlorides

Journal of the American Chemical Society

Carbon−Sulfur Bond-Forming Reductive Elimination Involving sp-, sp2-, and sp3-Hybridized Carbon. Mechanism, Steric Effects, and Electronic Effects on Sulfide Formation

Journal	Data powered by TypesetOrganic and Biomolecular Chemistry
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	1477-0520
Open Access	No