Photoplethysmographic (PPG) measurements from ambulatory subjects may suffer from unreliability due to body movements and missing data segments due to loosening of sensor. This paper describes an on-device reliability assessment from PPG measurements using a stack denoising autoencoder (SDAE) and multilayer perceptron neural network (MLPNN). The missing segments were predicted by a personalized convolutional neural network (CNN) and long-short term memory (LSTM) model using a short history of the same channel data. Forty sets of volunteers' data, consisting of equal share of healthy and cardiovascular subjects were used for validation and testing. The PPG reliability assessment model (PRAM) achieved over 95% accuracy for correctly identifying acceptable PPG beats out of total 5000 using expert annotated data. Disagreement with experts' annotation was nearly 3.5%. The missing segment prediction model (MSPM) achieved a root mean square error (RMSE) of 0.22, and mean absolute error (MAE) of 0.11 for 40 missing beats prediction using only four beat history from the same channel PPG. The two models were integrated in a standalone device based on quad-core ARM Cortex-A53, 1.2 GHz, with 1 GB RAM, with 130 MB memory requirement and latency ∼0.35 s per beat prediction with a 30 s frame. The present method also provides improved performance with published works on PPG quality assessment and missing data prediction using two public datasets, CinC and MIMIC-II under PhysioNet. © 2007-2012 IEEE.