Computational Fluid Dynamics (CFD) analysis have been carried out to evaluate the frictional pressure drop across the horizontal pipeline and different piping components, like elbows, orifices, gate and globe valves for non-Newtonian liquid through 0.0127 m pipe line. The mesh generation is done using GAMBIT 6.3 and FLUENT 6.3 is used for CFD analysis. The CFD results are verified with our earlier published experimental data. The CFD results show the very good agreement with the experimental values. © 2016, The Institution of Engineers (India).