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University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Journal of Antibiotics

Studies on self‐sensitivity of producer mutant vs. sensitivity of non‐producer parent and unrelated organism showed that versilin inhibited spore germination and sporulation in the self‐sensitive producer mutant, non‐producer parent Aspergillus versicolor N5 and the unrelated sensitive Trichophyton rubrum. Sporulation appeared to be more sensitive than spore germination. The inhibition of in vivo synthesis of protein was very marked, but inhibition of RNA and DNA was slight and moderate, respectively. Thus versilin was not specific in its action, but the principal sensitive site was protein synthesis, as further suggested by inhibition of polyU‐directed in vitro synthesis of polyphenylalanine. The activation of leucine was unaffected, but the formation of leucyl‐tRNA was severely inhibited in all three strains. The differences in sensitivities between the strains were the same, whether as whole cells or as cell‐free extracts. Thus the nature of the sensitive site appeared to be identical in the self‐sensitive producer and sensitive non‐producer or unrelated organism. Copyright © 1989, Wiley Blackwell. All rights reserved

Journal of Applied Bacteriology

Characterization of versilinâ€sensitive sites in selfâ€sensitive producer and sensitive nonâ€producer or unrelated organism

Aspergillus versicolor was grown in soil-compost medium at pH 4.0 for 10 days under diffused light to get A. versicolor-grown soil which was found to control experimental infection in jute by Macrophomina phaseolina to the extent of 56% in pot-culture experiment. © 1985 Martinus Nijhoff Publishers.

Plant and Soil

Biocontrol of Macrophomina root-rot disease of jute by an antagonistic organism, Aspergillus versicolor

MYCOVERSILIN, A NEW ANTIFUNGAL ANTIBIOTIC .3. MECHANISM OF ACTION ON A FILAMENTOUS FUNGUS TRICHOPHYTON-RUBRUM

Mycoversilin is active against filamentous fungi, being specifically inhibitory to Trichophyton rubrum, minimum inhibitory concentration being 15 μg/ml. Mycoversilin inhibits sporulation to the extent of 28.5 % even at the growth inhibitory concentration whereas inhibition of spore germination requires higher concentration. It has no effect on radial growth. Further it shows no action either on the release of UV absorbing materials or on the respiration of T. rubrum. However, the antibiotic inhibits in vivo synthesis of protein fairly strongly, DNA moderately and RNA slightly at the minimum inhibitory concentration. Cell-free protein synthesis is also strongly inhibited, the site of action being the inhibition of leucyl-tRNA formation by the antibiotic which has no action on leucine activation. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

The Journal of Antibiotics

Mycoversilin, a new antifungal antibiotic III. mechanism of action on a filamentous fungus trichophyton rubrum

The structure of a new antifungal antibiotic, mycoversilin, produced by Aspergillus versicolor (N5)l7 was determined as I by various spectroscopic and chemical methods. Mycoversilin is a unique polynuclear aromatic compound having two methyl and six hydroxyl groups and two ether linkages. The acetyl derivative prepared was found to have no antifungal property. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

Mycoversilin, a new antifungal antibiotic: II. Structure elucidation

In a heterogeneous degenerated culture the method of in situ screening of established agar colonies (the number screened being limited) cannot reveal the presence of an antibiotic‐producing organism even after mutagenic treatment, whereas the close‐range parallel streak method can succeed. Streaking a pour‐plate culture of an antibiotic‐sensitive organism by parallel streaks of mutagen‐treated inactive culture of the once producer afforded a better chance for regeneration of a degenerated culture. Copyright © 1980, Wiley Blackwell. All rights reserved

Journal	Journal of Antibiotics
Publisher	JAPAN ANTIBIOT RES ASSN
ISSN	0021-8820
Open Access	Yes