SUKHENDU MANDAL

Microbiology

AAYATTI MALLICK GUPTA

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Mycobacterium tuberculosis H37 Rv1222: structural insight in transcription inhibition.

Journal of Biomolecular Structure and Dynamics

Alternate sigma factor plays an important role for the survival of Mycobacterium tuberculosis in adverse environmental condition. Stress-induced sigma factors are major cause for expression of genes involved in pathogenesis, dormancy and various unusual environmental conditions. In the present work, an attempt has been made to characterize one of such M. tuberculosis (Mtb) sigma factor, SigE. The structures of Mtb-SigE and Mtb-β have been predicted using comparative modelling techniques and validated. Effort has also been implied to understand the nature of interaction of SigE with the core RNA polymerase subunits which have well identified the amino acid residues in the binding interface and prompted the fact that Mtb-β′ and Mtb-β interact with domain 2 and domain 4 of Mtb-SigE, respectively. Furthermore, intermolecular docking study predicted the interface between the Mtb-SigE and its putative promoter P-hsp20. The report confers the probable amino acid residues and the nitrogenous bases involved in the recognition of P-hsp20 by the sigma factor to initiate the transcription process. © 2015 Taylor and Francis.

Structural analysis of sigma e interactions with core RNA polymerase and its cognate P-hsp20 promoter of Mycobacterium tuberculosis

A comparative modeling and molecular docking study onMycobacterium tuberculosistargets involved in peptidoglycan biosynthesis

Secondary metabolites extracted from marine sponge associatedComamonas testosteroniandCitrobacter freundiias potential antimicrobials against MDR pathogens and hypothetical leads for VP40 matrix protein of Ebola virus: anin vitroandin silicoinvestigation

Amino acid composition analysis of secondary transport proteins fromEscherichia coliwith relation to functional classification, ligand specificity and structure

Nucleic Acids Research

Novel mechanism of gene regulation: the protein Rv1222 ofMycobacterium tuberculosisinhibits transcription by anchoring the RNA polymerase onto DNA

Mycobacterium tuberculosis H37 Rv1222: structural insight in transcription inhibition

Journal	Journal of Biomolecular Structure and Dynamics
Publisher	TAYLOR & FRANCIS INC
ISSN	0739-1102
Open Access	No