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Modification of cytotoxic effects of inorganic arsenic by a crude extract of allium sativum L. In mice
T DAS, A R CHOUDHURY, A SHARMA, G TALUKDER
Published in Informa Healthcare
1993
Volume: 31
   
Issue: 4
Pages: 316 - 320
Abstract
A crude extract of Allium sativum (100 mg/kg b.w./day) was administered orally to Swiss albino mice with a normal diet for 30 days. Sodium arsenite, a known cytotoxic agent, was given subcutaneously in normal saline to mice (0.1 mg/kg b.w. == 1/50 of LD50) on days 7,14,21 AND 30 of experiments. Chromosomal studies were conducted on bone marrow preparations following the colchicine-air-drying Giemsa schedule. The frequency of chromosomal aberrations was significantly lower in animals maintained on crude plant extract as a dietary supplement during exposure to sodium arsenite as compared to those treated with arsenite alone. A crude extract of Allium sativum thus protects against the clastogenicity of sodium arsenite. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
About the journal
JournalPharmaceutical Biology
PublisherInforma Healthcare
ISSN1388-0209