In the past few years, using microwave energy to heat and drive chemical reactions has become progressively more popular theme in the scientific community. Microwave-assisted organic synthesis is proving to be instrumental in the rapid synthesis of compounds with novel and improved biological activities. An efficiency of 'microwave flash heating' for chemical synthesis is the spectacular reduction in reaction times from days and hours to minutes and seconds, higher yields under milder reaction conditions, and higher product purities etc. Multicomponent reactions are precious tools for the making of various N-heterocycles and the N-heterocyclic scaffolds represent the central framework of many biologically active compounds. N-containing heterocycles hold a special place among pharmaceutically significant natural products and synthetic compounds needed for any developed human society. In the fields of organic chemistry, microwave irradiation is rapidly substituted the conventional heating methods in the world of multicomponent chemistry. In this review, we discuss only formation of N-containing heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions.