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Microwave-induced perchloric acid catalyzed novel solvent-free synthesis of 4-aryl-3,4-dihydropyrimidones via biginelli condensation
, A DATTA, B K BANIK
Published in HeteroCorporation
2007
Volume: 44
   
Issue: 4
Pages: 979 - 981
Abstract
(Chemical Equation Presented) We report here domestic microwave-induced perchloric acid-catalyzed solvent-free synthesis of various 4-aryl-3,4- dihydropyrimidones for the first time. In all the cases the yields are excellent and the mechanism follows a simple Biginelli condensation to produce the dihydropyrimidones in a few seconds. This procedure has been successfully employed to synthesize the mitotic kinesin EG5 inhibitor Monastrol (Figure I).
About the journal
JournalJournal of Heterocyclic Chemistry
PublisherHeteroCorporation
ISSN0022-152X
Open AccessNo