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Microwave assisted synthesis of 2,3-diaryl-6,7-dihydro-5H-pyrrolo[1,2 a]imidazoles through direct condensation of aryl 1,2-diketones and l-proline under solvent-free condition
S MAITY, S PATHAK,
Published in -
2013
Volume: 54
   
Issue: 20
Pages: 2528 - 2532
Abstract
Microwave irradiation of a solid mixture of aryl 1,2-diketones, l-proline, and ammonium acetate (excess) for 15 min produces 2,3-diaryl-6,7-dihydro-5H- pyrrolo[1,2-a]imidazoles in moderate yields. Mechanistically this one-pot three-component reaction generates pyrroloimidazoles through the intramolecular cyclization of 1,2-diimine intermediates derived from the condensation of aryl 1,2-diketones, l-proline, and ammonia in 1:1:1 molar proportion. The significant advantages of this methodology are cost-effectiveness, operational simplicity, and reduced reaction time. © 2013 Elsevier Ltd. All rights reserved.
About the journal
JournalTetrahedron Letters
Publisher-
ISSN0040-4039
Open AccessNo