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Long-term caffeine inhibits Ehrlich ascites carcinoma cell-induced induction of central GABAergic activity
S MUKHOPADHYAY, M K PODDAR
Published in KLUWER ACADEMIC/PLENUM PUBL
2000
Volume: 25
   
Issue: 11
Pages: 1457 - 1463
Abstract
Long-term administration (for 22-27 consecutive days) of caffeine (20 mg/kg/day p.o) developed tolerance to this drug by upregulating the central GABAergic activity. Development of Ehrlich ascites carcinoma (EAC) cell induced the whole brain GABAergic activity. But pretreatment of caffeine and continuation of its treatment in the course of development of EAC cells restored the EAC cell-induced change of GABAergic activity to control values. Thus, it may be concluded that caffeine (adenosine receptor antagonist) suppresses the EAC cell-induced induction of whole brain GABAergic activity in mice.
About the journal
JournalNeurochemical Research
PublisherKLUWER ACADEMIC/PLENUM PUBL
ISSN0364-3190