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Long-term caffeine consumption reverses tumor-induced suppression of the innate immune response in adult mice
A MANDAL, M K PODDAR
Published in GEORG THIEME VERLAG KG
2008
Volume: 74
   
Issue: 15
Pages: 1779 - 1784
Abstract
Caffeine (1,3,7-trimethylxanthine), the active principle alkaloid of coffee (Coffea arabica) and tea (Camellia sinensis) possesses a restraining effect on tumor-induced suppression of the specific immune response in adult mice. The present study deals with the effect of long-term consumption of caffeine in the development of Ehrlich ascites carcinoma (EAC) cells in adult Swiss female mice, in relation to the innate immune response and tumor growth. Although the consumption of caffeine alone for more than 12 consecutive days did not affect the innate immune response parameters, continuation of its treatment following intraperitoneal EAC cell inoculation not only reduced the in vivo tumor growth but also reduced/restored the EAC cell-induced suppression of the innate immune response. These results suggest that caffeine may inhibit in vivo tumor growth through reduction of the cancer cell-induced suppression of the innate immune response. Georg Thieme Verlag KG Stuttgart.
About the journal
JournalPlanta Medica
PublisherGEORG THIEME VERLAG KG
ISSN0032-0943