The cerebral ganglion of the earthworm, Eutyphoeus gammiei reveals mainly two types of neurosecretory cells (NSCs) - A and B. Cortical A cells stain intensely with AF and are differentiated into A1, A2 and A3 subtypes. The subcortical B cells, lying close to the neuropile stain lightly with AF. The axon terminals from the A2 cells and B cells form 'accumulation zone' rich in neurosecretory material (NSM) at the margin of neuropile. The cerebral ganglion including its outer connective tissue sheath (perineurium) in richly vascularised. Compact layer of visceral muscle cells around the cerebral ganglion assure a better mixing up of neurosecretion with blood besides protecting it from mechanical damage.