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Leishmanicidal and anticandidal activity of constituents of Indian edible mushroom astraeus hygrometricus
T K LAI, G BISWAS, S CHATTERJEE, A DUTTA, C PAL, J BANERJI,
Published in WILEY-V C H VERLAG GMBH
2012
PMID: 22899612
Volume: 9
   
Issue: 8
Pages: 1517 - 1524
Abstract
Two new lanostane-type triterpenes, 1 and 2, were isolated from Astraeus hygrometricus. The structures were established by IR, 1H- and 13C-NMR, MS, and X-ray crystallographic experiments. The triterpenes exhibited excellent in vitro toxicities against Candida albicans, comparable to standard antifungal antibiotics. The triterpene 2 significantly inhibited the growth of Leishmania donovani promastigotes in vitro. The triterpene skeleton may be considered a template structure in search for new compounds with anticandidal and leishmanicidal activity. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.
About the journal
JournalData powered by TypesetChemistry and Biodiversity
PublisherData powered by TypesetWILEY-V C H VERLAG GMBH
ISSN1612-1872
Open AccessNo