Iodine is a key component of thyroid hormones. Iodine deficiency as well as iodine excess causes thyroid disorders. Universal salt iodization has led to exposure to iodine above the recommended levels in environmentally iodine sufficient regions disrupting thyroid physiology and in turn affecting reproductive physiology. Effects of excess iodine on male reproductive organ is well studied but studies on ovarian and uterine structural changes are scanty. Hence the present study investigates the histological changes in the ovary and uterus after prolonged exposure to iodine in excess. The study clearly indicates changes in ovarian follicular and corpus luteum number and structure. This was also accompanied by altered luminal structure and number of secretory glands in the uterus. The probable cause was ovarian iodine accumulation and altered thyroid physiology. Thus prolonged exposure of iodine in excess altered the normal histological structure of ovary and uterus, posing detrimental to female reproductive system. © 2017, Association of Physiologists and Pharmacologists of India. All rights reserved.