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Interfacial energy driven distinctive pattern formation during the drying of blood droplets
M. Mukhopadhyay, R. Ray, M. Ayushman, P. Sood, M. Bhattacharyya, , S. DasGupta
Published in Academic Press Inc.
PMID: 32289626
Volume: 573
Pages: 307 - 316
Hypothesis: Dried blood droplet morphology may potentially serve as an alternative biomarker for several patho-physiological conditions. The deviant properties of the red blood cells and the abnormal composition of diseased samples are hypothesized to manifest through unique cell-cell and cell-substrate interactions leading to different morphological patterns. Identifying distinctive morphological trait from a large sample size and proposing confirmatory explanations are necessary to establish the signatory pattern as a potential biomarker to differentiate healthy and diseased samples. Experiments: Comprehensive experimental investigation was undertaken to identify the signatory dried blood droplet patterns. The corresponding image based analysis was in turn used to differentiate the blood samples with a specific haematological disorder “Thalassaemia” from healthy ones. Relevant theoretical analysis explored the role of cell-surface and cell-cell interactions pertinent to the formation of the distinct dried patterns. Findings: The differences observed in the dried blood patterns, specifically the radial crack lengths, were found to eventuate from the differences in the overall interaction energies of the system. A first-generation theoretical analysis, with the mean field approximation, also confirmed similar outcome and justified the role of the different physico-chemical properties of red blood cells in diseased samples resulting in shorter radial cracks. © 2020 Elsevier Inc.
About the journal
JournalJournal of Colloid and Interface Science
PublisherAcademic Press Inc.