Header menu link for other important links
X
Inhibition of leukemic U937 cell growth by induction of apoptosis, cell cycle arrest and suppression of VEGF, MMP-2 and MMP-9 activities by cytotoxin protein NN-32 purified from Indian spectacled cobra (Naja naja) venom
T DAS, S BHATTACHARYA, A BISWAS, S D GUPTA, A GOMES, A GOMES
Published in PERGAMON-ELSEVIER SCIENCE LTD
2013
Volume: 65
   
Pages: 1 - 4
Abstract
A cytotoxin NN-32 (6.7 kDa) from Indian cobra (Naja naja) venom inhibited human leukemic U937 cell growth as observed by Trypan blue dye exclusion method and cytotoxicity was confirmed by MTT assay. NN-32 induced apoptosis of U937 cell and cell cycle arrest of sub-G1 phase were revealed by FACS analysis. Increased Bax/Bcl-2 ratio, increased caspase 3 and 9 activities, cleaved PARP, decreased VEGF, MMP-2 and MMP-9 activities were observed after NN-32 treatment of U937 cell. Antileukemic activity of NN-32 on U937 cell may be due to activation of apoptosis, arresting cell cycle and antiangiogenesis activities. © 2013.
About the journal
JournalData powered by TypesetToxicon
PublisherData powered by TypesetPERGAMON-ELSEVIER SCIENCE LTD
ISSN0041-0101