In this study, we report a novel synthesis method, characterization and application of a new class of ferromagnetic cubic cobalt ferrite magnetic nanoparticles (MNPs) for hyperthermia therapy and temperature triggered drug release. The MNPs are characterized by XRD, TEM, FESEM, AC magnetic hysteresis and VSM. These MNPs were coated with folic acid and loaded with an anticancer drug. The drug release studies were done at two different temperatures (37 °C and 44 °C) with progress of time. It was found that higher release of drug took place at elevated temperature (44 °C). We have developed a temperature sensitive drug delivery system which releases the heat sensitive drug selectively as the particles are heated up under AC magnetic field and controlled release is possible by changing the external AC magnetic field. © 2016 Elsevier B.V.

C DEY

K BAISHYA

M M GOSWAMI

A GHOSH

K MANDAL

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Journal of Magnetism and Magnetic Materials

This work reports the application possibilities of cobalt ferrite (CoFe2O4) magnetic nanoparticles (CFMNPs) for stimuli responsive drug delivery by magnetic field induced hyperthermia technique. The CFMNPs were characterized by X-ray diffraction (XRD) with Rietveld analysis, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED), fourier transform infrared spectroscopy (FTIR), thermogravimetry and differential thermal analysis (TG-DTA), vibrating sample magnetometer (VSM) and superconducting quantum interference device (SQUID) magnetometry. Particles were functionalized with folic acid (FA) by EDC-NHS coupling method and loaded with anticancer drug (DOX) by activated folate ions. The drug release was studied as a function of time at two different temperatures (37 and 44 °C) under pH∼5.5 and 7. It was observed that the drug release rate is higher at elevated temperature (44 °C) and acidic pH∼5.5 as compared to our normal body temperature and pH∼7 using the CFMNPs. This way, we have developed a pH and temperature sensitive drug delivery system, which can release the anticancer drug selectively by applying ac magnetic field as under ac field particles are heated up. We have calculated the amount of heat generation by the particles around 1.67 °C per second at ∼600 Hz frequency. By MTT assay on cancer cell and normal cell, it was confirmed that CFMNPs are nontoxic and biocompatible in nature, which assures that our synthesized particles can be successfully used in localized cancer treatment by stimuli responsive drug delivery technique. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

ChemPhysChem

Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

Magnetic materials with high specific loss power (SLP) are desirable for;magnetic hyperthermia to minimise the amount of material required to;obtain the therapeutic temperature (42-46 degrees C) to destroy the;cancer cells. The exchange coupled core-shell structure and the;nanoclusters of magnetic nanoparticles having high SLP values are the;most suitable candidates for this purpose. Herein, a simple method has;been demonstrated for the synthesis of exchange coupled magnetic;nanoflowers consisting of gamma-Fe2O3 magnetic grains grown over the;surface of MnFe2O4 core. The aqueous ferrofluid of nanoflowers displayed;higher SLP values than single phase MnFe2O4 core. The intrinsic loss;parameter for the nanoflowers was 3.30 nH m(2) Kg(-1) at an applied;magnetic field of amplitude 250 Oe and frequency 113 kHz, which was;significantly higher than the commercially available ferrofluids. The;cytotoxicity of the nanoflowers were studied with HeLa cells. The;magnetic hyperthermia treatment for 30 min with 0.75 mg/mL ferrofluid of;the nanoflowers demonstrated a temperature rise to 46 degrees C and;decreased the cell viability to 17\% for HeLa cells. These nanoflowers;(size around 40-60 nm) showed better magnetic properties viz. higher;saturation magnetisation, initial susceptibility and lower coercivity,;making them a suitable candidate for biomedical applications.

Journal Of Magnetism And Magnetic Materials

Synthesis of exchange coupled nanoflowers for efficient magnetic;hyperthermia

Here we have discussed about designing the magnetic particles for hyperthermia therapy and done some studies in this direction. We have used oleylamine micelles as template to synthesize hollow-nanospheres (HNS) of magnetite by solvo-thermal technique. We have shown that oleylamine plays an important role to generate hollow particles. Structural analysis was done by XRD measurement and morphological measurements like SEM and TEM was performed to confirm the shape and size of hollow sphere particles. The detail magnetic measurements give an idea about the application of these HNS for magnetic heating in hyperthermia therapy. In vitro cytotoxicity studies reveal that tolerable dose rate for these particles can be significantly high and particles are non-toxic in nature. Being hollow in structure and magnetic in nature such materials will also be useful in other application fields like in drug delivery, drug release, arsenic and heavy metal removal by adsorption technique, magnetic separation etc. © 2016 Elsevier B.V. All rights reserved.

Micelles driven magnetite (Fe3O4) hollow spheres and a study on AC magnetic properties for hyperthermia application

Materials

Review on Microwave-Matter Interaction Fundamentals and Efficient Microwave-Associated Heating Strategies

Current Nanomedicine

Nano-Carrier Systems: An Overview of Poly-Art and Peptide Conjugates

Magnetic properties of Fe3O4 nano-hollow spheres

Cobalt-doped iron oxide nanoparticles were prepared by solution combustion technique. The structural and magnetic properties of the prepared samples were also investigated. The average crystallite size of cobalt ferrite (CoFe2 O4) magnetic nanoparticle was calculated using Scherrer equation, and it was found to be 16±5 nm. The particle size was measured by transmission electron microscope. This value was found to match with the crystallite size calculated by Scherrer equation corresponding to the prominent intensity peak (311) of X-ray diffraction. The high-resolution transmission electron microscope image shows clear lattice fringes and high crystallinity of cobalt ferrite magnetic nanoparticles. The synthesized magnetic nanoparticles exhibited the saturation magnetization value of 47 emu/g and coercivity of 947 Oe. The anti-microbial activity of cobalt ferrite nanoparticles showed better results as an anti-bacterial agent. The affinity constant was determined for the nanoparticles, and the cytotoxicity studies were conducted for the cobalt ferrite nanoparticles at different concentrations and the results are discussed. © 2015 Venkatesan et al.

Journal	Data powered by TypesetJournal of Magnetism and Magnetic Materials
Publisher	Data powered by TypesetElsevier B.V.
ISSN	0304-8853