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Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies
SUBARNA DUTTA, MAITREE BHATTACHARYYA, KAUSHIK SENGUPTA
Published in MDPI
2016
Volume: 5
   
Issue: 4
Abstract
Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively termed as laminopathies, the majority of which are characterized by irregularly shaped, fragile, and plastic nuclei. These nuclei are challenged to normal mechanotransduction and lead to disease phenotypes. Here, we review our current understanding of the nucleocytoskeleton coupling in mechanotransduction mediated by lamins. We also present an up-to-date understanding of the methods used to determine laminar elasticity both at the bulk and single molecule level.
About the journal
JournalCELLS
PublisherMDPI
ISSN2094-4748
Open AccessYes