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Immunochemical studies on a polysaccharide from Shigella dysenteriae type 2
S BASU, J PAL, C V N RAO, A N CHAKRABARTY, S G DASTIDAR
Published in -
1983
Volume: 20
   
Issue: 10
Pages: 1089 - 1093
Abstract
The polysaccharide isolated from Shigella dysenteriae type 2, strain NCTC 566, on Smith degradation and graded hydrolysis yielded three oligosaccharides which were characterised using methylation studies. Using homologous rabbit antiserum and the monosaccharides that constituted the polysaccharide and the oligosaccharides isolated from it and the cross-reactions in some type-specific pneumococcal antisera, immunochemical specificities of different sugar groupings in the polysaccharide molecule were determined. These results indicated that N-acetylglucosamine was the immunodominant sugar in the polysaccharide and the oligosaccharide isolated from the Smith-degraded product and having the structure {A figure is presented} gave maximum inhibition of the specific precipitation. © 1983.
About the journal
JournalMolecular Immunology
Publisher-
ISSN0161-5890