In the present study, the chloroform and methanol extracts from Litchi chinensis leaf were evaluated for their protective effects on paracetamol-induced liver damage in Wistar albino rats. Serum biochemical parameters viz. serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), total protein, bilirubin, cholesterol, triglycerides; and liver biochemical parameters such as lipid peroxidation, reduced glutathione (GSH) content and catalase (CAT) activities were evaluated. All biochemical observations indicated that both the test extracts exerted significant hepatoprotective efficacy against paracetamol-induced hepatic damage in rats. The methanol extract was found to be more effective than chloroform extract. Therefore, from the present study it can be concluded that L. chinensis leaf had remarkable hepatoprotective activity in rats. © IDOSI Publications, 2014.