Objectives: Aim of the study is to find therapeutic potentials of aqueous Curry Leaf (Murraya koenigii) Extract (CuLE) against lead induced oxidative damage in hepatic tissue. The objectives are to study the alterations of various stress parameters in lead induced hepatotoxicity and amelioration of the same with CuLE. Methods: Rats were intraperitoneally injected with lead acetate (15mg/kg body weight). Another group was pre-treated with CuLE (50 mg / kg, fed orally).The positive control group was fed CuLE (50 mg / kg), and the control animals received vehicle treatment i.p. for 7 consecutive days. Concentration of lead in liver was estimated by AAS study. The alterations in the activity of the different bio-markers of hepatic damage, biomarkers of oxidative stress, activities of the antioxidant and some of the mitochondrial enzymes were studied. Histomorphology and alteration in tissue collagen level was studied through H-E staining and Sirius red staining respectively. Quantification of tissue collagen content was evaluated using confocal microscopy. Results: Lead caused alterations in all the parameters studied. All these changes were mitigated when the rats were pre-treated with CuLE. Concentration of lead in liver tissue was also decreased following pre-treatment with CuLE. Conclusions: The results indicate that the CuLE ameliorates lead-induced hepatic damage in experimental rats by antioxidants present in the extract. CuLE may have future therapeutic relevance in the prevention of lead-induced hepatotoxicity in humans exposed occupationally or environmentally to this toxic heavy metal and may be used for development of new hepatoprotective drugs of herbal origin with less cytotoxic effects.