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Genotoxicity of sennosides on the bone marrow cells of mice
M J MUKHOPADHYAY, A SAHA, A DUTTA, , A MUKHERJEE
Published in PERGAMON-ELSEVIER SCIENCE LTD
1998
Volume: 36
   
Issue: 11
Pages: 937 - 940
Abstract
Preparations of a number of plants which contain hydroxyanthraquinones as active constitutents are used worldwide for their laxative effect. Anthraquinone glycosides of Cassia angustifolia and C. fistula were investigated for their ability to induce a clastogenic effect on the bone marrow cells of Swiss albino mice. The endpoints screened were chromosomal aberrations and frequency of aberrant cells. Oral exposure to doses of these anthraquinones and their equivalent amount in leaf and pod extracts did not induce significant numbers of chromosomal aberrations or aberrant cells. The results indicate that anthraquinone sennoside B and rhein are weakly genotoxic. Copyright (C) 1998 Elsevier Science Ltd.
About the journal
JournalData powered by TypesetFood and Chemical Toxicology
PublisherData powered by TypesetPERGAMON-ELSEVIER SCIENCE LTD
ISSN0278-6915