The fruits of the plant Garcinia indica, as well as other species of the genus Garcinia, are used both as food and in folkloric medicine. Recently extracts of G. indica fruits also have been used in commercial weight-loss formulations. In the present study, we evaluated the genotoxic potential of G. indica extract in mice. Mice were treated with single doses of a lyophilized hydroxy-methanol extract of the rind of G. indica fruit dissolved in water. Doses of 15–240 mg/kg body weight were administered orally or intraperitonially. Bone marrow cells were evaluated for chromosomal aberrations (CAs) and sister-chromatid exchanges (SCEs). The extract produced dose-dependent increases in both the endpoints, while the rate of cellular proliferation of the bone marrow cells remained unaffected. The minimum effective concentrations for inducing chromosomal aberrations and SCEs were 120 and 30 mg/kg, respectively. The results of the study indicate that a crude extract of the fruit-rind of G. indica is genotoxic in mice. © 2015, Archana Sharma Foundation of Calcutta.