Nanoscale delivery systems have numerous potential applications in the food industry for encapsulating, protecting, and releasing bioactive agents, such as nutraceuticals and vitamins. In the recent past, a deluge of interest has developed in the field of nutraceuticals. In the search for an alternative source of health, the importance of nutraceuticals or food supplements has become prominent. However, a number of challenges are associated with the enhancement of these dietary supplements from concept to commercialization. The greatest hurdles experienced are the limited shelf life, proper delivery to the targeted sites, and most importantly ascertaining the overall safety of the nutraceuticals on consumption. The development of nanoscale delivery systems, solid dispersions, liposomes, nanoemulsions, nanocapsules, etc. has taken care of most of these problems head-on. The present article highlights the challenges associated with the development of nutraceuticals at a large scale and their introduction as integral components into foods. An overview of the different safety measures that can be pursued while developing several nanoscale formulations has been discussed. In addition, the cost-effectiveness of such procedures is also elaborated, keeping in mind the market aspect. Thus, the final products will be formulated so as to be safe, economically viable, and effective in promoting good health. © 2017 Elsevier Inc.. All rights reserved.