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Excision wound healing activity of a common biosurfactant produced by Pseudomonas sp.
S SANA, S DATTA, , B AUDDY, M GUPTA, H CHATTOPADHYAY,
Published in Elsevier GmbH
2018
Volume: 23
   
Pages: 47 - 52
Abstract
Background: Wound is an inherent process to regenerate the cellular cohesion of tissue. Present study deal with the accelerating potentiality of rhamnolipid produced by P. aeruginosa C2 using fat of Catla catla fish as an economic substrate to heal wound in a shorter time. Methodology: An ointment containing rhamnolipid (5 g/l) was administered on the back of each wister rat after creating excision wound of 50 mm2. The examined parameters were percentage wound reduction, tissue tensile strength, DNA, protein, hexosamine content and histological study of regenerated tissue and TNF α estimation from blood serum. Main findings: Rhamnolipid enhanced the rate of wound contraction within 10 days in comparison to untreated control group (p < 0.05). The higher tensile strength of the rhamnolipid treated group signified (p < 0.05) improved collagenesis which was supported by remarkably higher DNA, total protein and hexosamine content of the regenerated tissue at the wound site in comparison to untreated control group. Diminishing level of TNF-α in serum, histopathological studies revealed significant healing effect of rhamnolipid. Moreover activity of rhamnolipid against Staphylococcus aureus ATCC6588 may have contributed towards wound healing by protecting the wound site from bacterial contamination. Conclusions: The results of this study have expressed that rhamnolipid can be used as a wound healing material for excision wound. Rhamnolipid can provide additional advantage in healing by showing protection from bacterial infection. © 2018
About the journal
JournalData powered by TypesetWound Medicine
PublisherData powered by TypesetElsevier GmbH
ISSN2213-9095
Open AccessNo