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Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines
Bodhak C., Mandal S., Dey P., Mukherjee S.K.,
Published in Elsevier B.V.
Volume: 4
An ultrasound assisted methodology has been developed for rapid synthesis of a series of biologically important 2-iminothiazolines from easily available α-bromoketones and thioureas under solvent- and catalyst-free conditions at room temperature in open air. The 2-iminothiazolines are found to exhibit moderate activity against both the representative Gram positive and Gram negative bacteria, suggesting possible scope of using them as antimicrobials. Additionally Suzuki cross-coupling of 5-bromo-2-iminothiazolines with organoboronic acids produced fully substituted 5-aryl-2-iminothiazolines in good yield. © 2022 The Author(s)
About the journal
JournalData powered by TypesetResults in Chemistry
PublisherData powered by TypesetElsevier B.V.
Open AccessNo