S D GUPTA

I B CHATTERJEE

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Effects of some aldehyde binding agents on the in vitro synthesis of L-ascorbic acid.

Die Naturwissenschaften

d-Glucofuranosiduronolactone conjugates, namely, semicarbazone, oxime, cyanohydrin, and thioacetal of d-glucurono-1,4-lactone, were converted to l-ascorbic acid by an enzyme system present in rat, goat, or rabbit liver microsomes. Guinea pig liver microsomes were ineffective. Neither methyl-d-glucofuranosiduronolactone nor any glucopyranosiduronic acid conjugates examined were converted into l-ascorbic acid. Methods of preparation and properties of d-glucurono-1,4-lactone semicarbazone and d-glucurono-1,4-lactone oxime have been described and a tentative mechanism of enzymic reduction of the conjugates into l-gulono-1,4-lactone has been suggested. A conjugate of d-glucurono-1,4-lactone and imidazole, which is a substrate for the microsomal enzyme leading to synthesis of l-ascorbic acid, has been identified in the urine of rat treated with chloretone, barbital, and 1,2-benzanthracene. It has been indicated that the enhanced synthesis of l-ascorbic acid after administration of various drugs and toxic chemical compounds is due to the induced formation of this endogenous substrate. © 1970.

Journal	Data powered by TypesetDie Naturwissenschaften
Publisher	Data powered by TypesetSpringer-Verlag
ISSN	0028-1042