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Effects of chronic vanadium pentoxide administration on L ascorbic acid metabolism in rats: influence of L ascorbic acid supplementation
D CHAKROBORTY, A BHATTACHARYYA, K MAJUMDAR, G C CHATTERJEE
Published in -
1977
Volume: 47
   
Issue: 1
Pages: 81 - 87
Abstract
Rats toxicated with vanadium pentoxide showed drastic retardation in growth rate and supplementation of L ascorbic acid to these rats could not reverse this effect. The urinary excretion of L ascorbic acid and D glucuronic acid was decreased in the toxicated group of rats. Considerable lowering of L ascorbic acid content of the liver tissues of rats was observed under vanadium toxicated conditions. Supplementation of L ascorbic acid to this group raised the tissue Vitamin C reserve considerably. The normal histological patterns of the liver and kidney tissues of rats were severely disturbed under vanadium toxicated conditions. L ascorbic acid supplementation to this group of rats showed marked signs of restoration in this respect. Vanadium pentoxide treatment brought about a significant reduction in the biosynthetic capacity of L ascorbic acid, along with an enhanced utilization of this vitamin. Subsequent supplementation of L ascorbic acid to the toxicated group of rats was found to be effective in reversing these effects almost to the basal level.
About the journal
JournalInternational Journal for Vitamin and Nutrition Research
Publisher-
ISSN0300-9831