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Effect of corticosterone on adrenal 5-ENE-3β-hydroxysteroid dehydrogenase in estrogen-treated rats
P K GHOSH, N M BISWAS
Published in -
1983
Volume: 19
   
Issue: 3
Pages: 1309 - 1312
Abstract
Treatment of adult male rats with estradiol-17β for 7 days results in adrenal hyperplasia, increased level of serum ACTH along with reduction in serum level of α2u-globulin and inhibition of adrenal 5-ene-3β-hydroxysteroid dehydrogenase (5-ene-3β-HSD) activity. Administration of corticosterone in estrogen-treated rats reverses the effects of estrogen while in normal rats corticosterone treatment reduces adrenal weight, serum ACTH and adrenal 5-ene-3β-HSD activity. In vitro experiments show that α2u-globulin fails to change adrenal 5-ene-3β-HSD activity in corticosterone pretreated rats while in normal and estrogen pretreated rats α2u-globulin increases 5-ene-3β-HSD activity. © 1983.
About the journal
JournalJournal of Steroid Biochemistry
Publisher-
ISSN0022-4731