Treatment of adult male rats with estradiol-17β for 7 days results in adrenal hyperplasia, increased level of serum ACTH along with reduction in serum level of α2u-globulin and inhibition of adrenal 5-ene-3β-hydroxysteroid dehydrogenase (5-ene-3β-HSD) activity. Administration of corticosterone in estrogen-treated rats reverses the effects of estrogen while in normal rats corticosterone treatment reduces adrenal weight, serum ACTH and adrenal 5-ene-3β-HSD activity. In vitro experiments show that α2u-globulin fails to change adrenal 5-ene-3β-HSD activity in corticosterone pretreated rats while in normal and estrogen pretreated rats α2u-globulin increases 5-ene-3β-HSD activity. © 1983.

P K GHOSH

N M BISWAS

University of Calcutta (informally known as Calcutta University or CU) is a collegiate public state university located in Kolkata, West Bengal, India.&nbsp;Within India it is recognized as a &quot;Five-Star University&quot; and accredited &quot;A&quot; Grade by National Assessment and Accreditation Council.

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The University of Calcutta has secured the Fifth position among the Universities of India in the prestigious &quot;Indian University Ranking 2019&quot; list, released by the NIRF of the Ministry of Human Resource Development, Government of India.

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It was established on 24 January 1857, and was one of the first institutions in Asia to be established as a multidisciplinary and Western-style university. Its alumni and faculty include several heads of state, heads of government, social reformers, prominent artists, only academy award winner and Dirac medal winner in India, many Fellows of the Royal Society and five Nobel laureates as of 2019 which is highest in South Asia.

University Of Calcutta

Effect of corticosterone on adrenal 5-ENE-3β-hydroxysteroid dehydrogenase in estrogen-treated rats

Journal of Steroid Biochemistry

The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal δ5-3β(delta 5-3 beta) hydroxysteroid (δ5-3β- HSD) and testicular 17β (17 beta) hydroxysteroid dehydrogenase (17β-HSD) activities, decreased the serum levels of testosterone and inhibited spermatogenesis. When toads were treated with corticosterone a significant rise of serum corticosterone was noted while metapyrone treatment appeared to decrease serum corticosterone levels. It is concluded that adrenocortical hormone plays an indirect role in testicular activity in toads during the breeding season.

Life Sciences

Influence of adrenal cortex on testicular activity in the toad during the breeding season

Experientia

Prevention of estrogenic inhibition of adrenal 686-1686-1686-1686-2686-2686-2in rats

The hepatic synthesis of the androgendependent urinary protein in the rat, called a2u globulin, is strongly inhibited by estrogens. In mature male rats, treatment with estradiol-17β (0.5 μg/g body weight) completely inhibitsα2u synthesis within 6-7 days. Following withdrawal of estrogen treatmentα2u synthesis is not reinitiated for approximately 20 days. Parabiotic joining of estrogensuppressed male rats with their normal littermates within this lag period fails to change the preparabiotic pattern ofα2u synthesis in the respective partners. Besides estradio 1-17β, other estrane derivatives such as estrone, estriol and estradiol-17α were also found to inhibit the synthesis ofα2u globulin. All of the above estrane derivatives which inhibitα2u synthesis are also found to inhibit the uptake of 5α-dihydrotestosterone by the hepatic cytosol androgen binding protein of the mature male rat. Unlike cycloheximide, a known translational inhibitor, estradiol-17β does not inhibitα2u synthesis in the perfused rat liver. © 1975 by The Endocrine Society.

Endocrinology

Estrogenic inhibition of the hepatic synthesis of Î±2u globulin in the rat

Journal of Endocrinology

EFFECT OF CORTICOSTERONE ON SERUM CONCENTRATIONS OF α2u-GLOBULIN AND ON SPERMATOGENESIS IN OESTROGEN-TREATED RATS

Biochimica et Biophysica Acta (BBA) - General Subjects

The effect of dietary protein on the excretion of α2u, the sex-dependent protein of the adult male rat

A Radioimmunoassay for Rat Plasma ACTH

Effect of corticosterone on adrenal 5-ENE-3Î²-hydroxysteroid dehydrogenase in estrogen-treated rats

Journal	Journal of Steroid Biochemistry
Publisher	-
ISSN	0022-4731